Hadid died after suffering a heart attack at a Miami hospital, where she was receiving treatment for bronchitis, her design firm said in a statement on Thursday.
Born in Baghdad in October 31, 1950, Hadid first studied mathematics at the American University in Lebanon, before pursuing architecture at the Architectural Association in London in 1972.
In 1979, she established her own practice in London, the Zaha Hadid Architects.
Hadid, who was known for her neofuturistic design, was recently awarded the 2016 Royal Gold Medal in architecture by the Royal Institute of British Architects.
Hadid designed the London Aquatics Centre, which was used during the 2012 London Olympics. She also designed the Al Wakrah Stadium, which is under construction for the 2022 Qatar World Cup.